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KMID : 0369820070370060365
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Jorunal of Korean Pharmaceutical Sciences
2007 Volume.37 No. 6 p.365 ~ p.368
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Low-frequency Ultrasound Enhanced Transdermal Drug Delivery Across Rat Skin
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Lee Hwa-Jin
Kim Jong-Youl
Park Jin-Nam
Shin Young-Hee
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Abstract
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The primary aim of this study was to investigate the enhancement effect of low-frequency ultrasound on skin permeation. In vitro permeation experiments were performed using Franz modified diffusion cells with ketoprofen as model drug. The effect of various ultrasound factors-ultrasound application mode (continuous mode and discontinuous mode), ultrasound intensity (0.26 , and 0.29 ) and duty cycle (3%, 16%, 50%, and 83%) were studied. The highest permeation was observed at 0.29 intensity, 50% duty cycle, and discontinuous mode. The result suggested the feasibility of low frequency ultrasound application for the phonophoretic transdermal drug delivery system.
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KEYWORD
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Phonophoretic, Low frequency ultrasound, Transdermal delivery, Ketoprofen
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